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Bioinformatics (Oxford, England) DOI:10.1093/bioinformatics/btp190

Identifying novel constrained elements by exploiting biased substitution patterns.

Publication TypeJournal Article
Year of Publication2009
AuthorsGarber, M, Guttman, M, Clamp, M, Zody, MC, Friedman, N, Xie, X
JournalBioinformatics (Oxford, England)
Volume25
Issue12
Pagesi54-62
Date Published2009/06/15
ISSN1367-4803
Abstract

Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate of mutation and have ignored selection acting on the pattern of mutations.

URLhttp://bioinformatics.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=19478016
DOI10.1093/bioinformatics/btp190
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19478016?dopt=Abstract