Scientific Publications

Identifying novel constrained elements by exploiting biased substitution patterns.

Publication TypeJournal Article
AuthorsGarber, M., Guttman M., Clamp M., Zody MC, Friedman N., and Xie X.
AbstractComparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate of mutation and have ignored selection acting on the pattern of mutations.
Year of Publication2009
JournalBioinformatics (Oxford, England)
Volume25
Issue12
Pagesi54-62
Date Published (YYYY/MM/DD)2009/06/15
ISSN Number1367-4803
DOI10.1093/bioinformatics/btp190
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19478016?dopt=Abstract