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PloS one DOI:10.1371/journal.pone.0006143

microRNA expression during trophectoderm specification.

Publication TypeJournal Article
Year of Publication2009
AuthorsViswanathan, SR, Mermel, CH, Lu, J, Lu, CW, Golub, TR, Daley, GQ
JournalPloS one
Volume4
Issue7
Pagese6143
Date Published2009/07/03
Abstract

Segregation of the trophectoderm from the inner cell mass of the embryo represents the first cell-fate decision of mammalian development. Transcription factors essential for specifying trophectoderm have been identified, but the role of microRNAs (miRNAs) in modulating this fate-choice has been largely unexplored. We have compared miRNA expression in embryonic stem cell (ESC)-derived trophectoderm and in staged murine embryos to identify a set of candidate miRNAs likely to be involved in trophectoderm specification.

URLhttp://dx.plos.org/10.1371/journal.pone.0006143
DOI10.1371/journal.pone.0006143
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19582159?dopt=Abstract