|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Viswanathan, SR, Mermel, CH, Lu, J, Lu, CW, Golub, TR, Daley, GQ|
Segregation of the trophectoderm from the inner cell mass of the embryo represents the first cell-fate decision of mammalian development. Transcription factors essential for specifying trophectoderm have been identified, but the role of microRNAs (miRNAs) in modulating this fate-choice has been largely unexplored. We have compared miRNA expression in embryonic stem cell (ESC)-derived trophectoderm and in staged murine embryos to identify a set of candidate miRNAs likely to be involved in trophectoderm specification.