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Genome biology DOI:10.1186/gb-2009-10-8-r88

Assisted assembly: how to improve a de novo genome assembly by using related species.

Publication TypeJournal Article
Year of Publication2012
AuthorsGnerre, S, Lander, ES, Lindblad-Toh, K, Jaffe, DB
JournalGenome biology
Volume10
Issue8
PagesR88
Date Published2012/01/09
ISSN1465-6906
Abstract

We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.

URLhttp://genomebiology.com/content/10/8/R88
DOI10.1186/gb-2009-10-8-r88
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19712469?dopt=Abstract