Assisted assembly: how to improve a de novo genome assembly by using related species.
Genome Biol
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Abstract | We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly. |
Year of Publication | 2009
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Journal | Genome Biol
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Volume | 10
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Issue | 8
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Pages | R88
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Date Published | 2009
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ISSN | 1474-760X
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URL | |
DOI | 10.1186/gb-2009-10-8-r88
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PubMed ID | 19712469
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PubMed Central ID | PMC2745769
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