|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Pizzirani, D, Roberti, M, Grimaudo, S, Di Cristina, A, Pipitone, RM, Tolomeo, M, Recanatini, M|
|Journal||Journal of medicinal chemistry|
With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.