You are here

Journal of medicinal chemistry DOI:10.1021/jm900907s

Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells.

Publication TypeJournal Article
Year of Publication2009
AuthorsPizzirani, D, Roberti, M, Grimaudo, S, Di Cristina, A, Pipitone, RM, Tolomeo, M, Recanatini, M
JournalJournal of medicinal chemistry
Volume52
Issue21
Pages6936-40
Date Published2009/11/12
ISSN0022-2623
Abstract

With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.

URLhttp://dx.doi.org/10.1021/jm900907s
DOI10.1021/jm900907s
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19764793?dopt=Abstract