Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells.

J Med Chem
Authors
Keywords
Abstract

With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.

Year of Publication
2009
Journal
J Med Chem
Volume
52
Issue
21
Pages
6936-40
Date Published
2009 Nov 12
ISSN
1520-4804
URL
DOI
10.1021/jm900907s
PubMed ID
19764793
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