|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Pizzirani, D, Roberti, M, Grimaudo, S, Di Cristina, A, Pipitone, RMaria, Tolomeo, M, Recanatini, M|
|Journal||J Med Chem|
|Date Published||2009 Nov 12|
|Keywords||Antineoplastic Agents, Apoptosis, Biphenyl Compounds, Cell Differentiation, HL-60 Cells, Humans, K562 Cells, Ketones, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Proto-Oncogene Proteins c-bcl-2, Spiro Compounds, Structure-Activity Relationship, Terphenyl Compounds|
With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.
|Alternate Journal||J. Med. Chem.|