Scientific Publications

Empirical Bayes analysis of quantitative proteomics experiments.

Publication TypeJournal Article
AuthorsMargolin, AA, Ong SE, Schenone M., Gould R., Schreiber SL, Carr SA, and Golub T. R.
AbstractAdvances in mass spectrometry-based proteomics have enabled the incorporation of proteomic data into systems approaches to biology. However, development of analytical methods has lagged behind. Here we describe an empirical Bayes framework for quantitative proteomics data analysis. The method provides a statistical description of each experiment, including the number of proteins that differ in abundance between 2 samples, the experiment's statistical power to detect them, and the false-positive probability of each protein.
Year of Publication2009
JournalPloS one
Volume4
Issue10
Pagese7454
Date Published (YYYY/MM/DD)2009/10/14
DOI10.1371/journal.pone.0007454
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19829701?dopt=Abstract