Scientific Publications

Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

Publication TypeJournal Article
AuthorsWang, Q., and Schreiber SL
AbstractA copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.
Year of Publication2009
JournalOrganic letters
Volume11
Issue22
Pages5178-80
Date Published (YYYY/MM/DD)2009/11/19
ISSN Number1523-7060
DOI10.1021/ol902079g
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19860425?dopt=Abstract