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Organic letters DOI:10.1021/ol902079g

Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

Publication TypeJournal Article
Year of Publication2009
AuthorsWang, Q, Schreiber, SL
JournalOrganic letters
Volume11
Issue22
Pages5178-80
Date Published2009/11/19
ISSN1523-7060
Abstract

A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.

URLhttp://dx.doi.org/10.1021/ol902079g
DOI10.1021/ol902079g
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19860425?dopt=Abstract