Scientific Publications

Genome sequence, comparative analysis, and population genetics of the domestic horse.

Publication TypeJournal Article
AuthorsWade, CM, Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear TL, Adelson DL, Bailey E., Bellone RR, Blöcker H., Distl O., Edgar RC, Garber M., Leeb T., Mauceli E., MacLeod JN, Penedo MC, Raison JM, Sharpe T., Vogel J., Andersson L., Antczak DF, Biagi T., Binns MM, Chowdhary BP, Coleman SJ, Della Valle G., Fryc S., Guérin G., Hasegawa T., Hill EW, Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson JR, Murray J., Nergadze SG, Onofrio R., Pedroni S., Piras MF, Raudsepp T., Rocchi M., Røed KH, Ryder OA, Searle S., Skow L., Swinburne JE, Syvänen AC, Tozaki T., Valberg SJ, Vaudin M., White JR, Zody MC, Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Lander E. S., and Lindblad-Toh K.
AbstractWe report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
Year of Publication2009
JournalScience (New York, N.Y.)
Volume326
Issue5954
Pages865-7
Date Published (YYYY/MM/DD)2009/11/06
ISSN Number0036-8075
DOI10.1126/science.1178158
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19892987?dopt=Abstract