Genome sequence, comparative analysis, and population genetics of the domestic horse.

Science

Authors	C Wade Giulotto Sigurdsson Zoli Gnerre Imsland T Lear D Adelson Bailey R Bellone Blöcker Distl R Edgar Garber Leeb Mauceli J MacLeod M Penedo J Raison Sharpe Vogel Andersson D Antczak Biagi M Binns B Chowdhary S Coleman Della Valle Fryc Guérin Hasegawa E Hill Jurka Kiialainen Lindgren Liu Magnani J Mickelson Murray S Nergadze Onofrio Pedroni M Piras Raudsepp Rocchi K Røed O Ryder Searle Skow J Swinburne A Syvänen Tozaki S Valberg Vaudin J White M Zody Broad Institute Genome Sequencing Platform Broad Institute Whole Genome Assembly Team E Lander K Lindblad-Toh
Keywords	Animals Female Humans Genes Computational Biology Genome Haplotypes Dogs Molecular Sequence Data Chromosome Mapping Evolution, Molecular Phylogeny Sequence Analysis, DNA DNA Copy Number Variations Repetitive Sequences, Nucleic Acid Chromosomes, Mammalian Synteny Centromere Animals, Domestic Horses
Abstract	We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
Year of Publication	2009
Journal	Science
Volume	326
Issue	5954
Pages	865-7
Date Published	2009 Nov 06
ISSN	1095-9203
URL	http://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=19892987
DOI	10.1126/science.1178158
PubMed ID	19892987
PubMed Central ID	PMC3785132
Links	Google Scholar DOI PubMed
Grant list	098051 / Wellcome Trust / United Kingdom