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Science DOI:10.1126/science.1178158

Genome sequence, comparative analysis, and population genetics of the domestic horse.

Publication TypeJournal Article
Year of Publication2009
AuthorsWade, CM, Giulotto, E, Sigurdsson, S, Zoli, M, Gnerre, S, Imsland, F, Lear, TL, Adelson, DL, Bailey, E, Bellone, RR, Blöcker, H, Distl, O, Edgar, RC, Garber, M, Leeb, T, Mauceli, E, MacLeod, JN, Penedo, MCT, Raison, JM, Sharpe, T, Vogel, J, Andersson, L, Antczak, DF, Biagi, T, Binns, MM, Chowdhary, BP, Coleman, SJ, Della Valle, G, Fryc, S, Guérin, G, Hasegawa, T, Hill, EW, Jurka, J, Kiialainen, A, Lindgren, G, Liu, J, Magnani, E, Mickelson, JR, Murray, J, Nergadze, SG, Onofrio, R, Pedroni, S, Piras, MF, Raudsepp, T, Rocchi, M, Røed, KH, Ryder, OA, Searle, S, Skow, L, Swinburne, JE, Syvänen, AC, Tozaki, T, Valberg, SJ, Vaudin, M, White, JR, Zody, MC, Lander, ES, Lindblad-Toh, K
Corporate AuthorsBroad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team
JournalScience
Volume326
Issue5954
Pages865-7
Date Published2009 Nov 06
ISSN1095-9203
KeywordsAnimals, Animals, Domestic, Centromere, Chromosome Mapping, Chromosomes, Mammalian, Computational Biology, DNA Copy Number Variations, Dogs, Evolution, Molecular, Female, Genes, Genome, Haplotypes, Horses, Humans, Molecular Sequence Data, Phylogeny, Repetitive Sequences, Nucleic Acid, Sequence Analysis, DNA, Synteny
Abstract

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=19892987
DOI10.1126/science.1178158
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19892987?dopt=Abstract

Alternate JournalScience
PubMed ID19892987
PubMed Central IDPMC3785132
Grant List098051 / / Wellcome Trust / United Kingdom