You are here

Science (New York, N.Y.) DOI:10.1126/science.1178158

Genome sequence, comparative analysis, and population genetics of the domestic horse.

Publication TypeJournal Article
Year of Publication2009
AuthorsWade, CM, Giulotto, E, Sigurdsson, S, Zoli, M, Gnerre, S, Imsland, F, Lear, TL, Adelson, DL, Bailey, E, Bellone, RR, Blöcker, H, Distl, O, Edgar, RC, Garber, M, Leeb, T, Mauceli, E, MacLeod, JN, Penedo, MC, Raison, JM, Sharpe, T, Vogel, J, Andersson, L, Antczak, DF, Biagi, T, Binns, MM, Chowdhary, BP, Coleman, SJ, Della Valle, G, Fryc, S, Guérin, G, Hasegawa, T, Hill, EW, Jurka, J, Kiialainen, A, Lindgren, G, Liu, J, Magnani, E, Mickelson, JR, Murray, J, Nergadze, SG, Onofrio, R, Pedroni, S, Piras, MF, Raudsepp, T, Rocchi, M, Røed, KH, Ryder, OA, Searle, S, Skow, L, Swinburne, JE, Syvänen, AC, Tozaki, T, Valberg, SJ, Vaudin, M, White, JR, Zody, MC, Broad Institute Genome Sequencing, P, Broad Institute Whole Genome Assembly, T, Lander, ES, Lindblad-Toh, K
JournalScience (New York, N.Y.)
Date Published2009/11/06

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.