Antiplasmodial activity of piperazine sulfonamides.

Bioorg Med Chem Lett
Authors
Keywords
Abstract

A high-throughput screening program identified two piperazine sulfonamides with activity against Plasmodium falciparum. Both screening positives had three structural features with potential liabilities: furanyl, thiourea and nitrophenyl groups. The furan could be replaced with no loss of activity, replacement of the nitrophenyl led to some loss of activity, and any attempt to replace the thiourea led to a significant decrease in activity, which implicates this reactive functional group's role in the antiplasmodial activity of this compound class.

Year of Publication
2010
Journal
Bioorg Med Chem Lett
Volume
20
Issue
1
Pages
218-21
Date Published
2010 Jan 01
ISSN
1464-3405
URL
DOI
10.1016/j.bmcl.2009.10.130
PubMed ID
19914069
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