Scientific Publications

Antiplasmodial activity of piperazine sulfonamides.

Publication TypeJournal Article
AuthorsMartyn, DC, Cortese JF, Tyndall E., Dick J., Mazitschek R., Munoz B., and Clardy J.
AbstractA high-throughput screening program identified two piperazine sulfonamides with activity against Plasmodium falciparum. Both screening positives had three structural features with potential liabilities: furanyl, thiourea and nitrophenyl groups. The furan could be replaced with no loss of activity, replacement of the nitrophenyl led to some loss of activity, and any attempt to replace the thiourea led to a significant decrease in activity, which implicates this reactive functional group's role in the antiplasmodial activity of this compound class.
Year of Publication2010
JournalBioorganic & medicinal chemistry letters
Volume20
Issue1
Pages218-21
Date Published (YYYY/MM/DD)2010/01/01
ISSN Number0960-894X
DOI10.1016/j.bmcl.2009.10.130
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19914069?dopt=Abstract