| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Smart, AC, Margolis, CA, Pimentel, H, He, MXiao, Miao, D, Adeegbe, D, Fugmann, T, Wong, K-K, Van Allen, EM |
| Journal | Nat Biotechnol |
| Volume | 36 |
| Issue | 11 |
| Pages | 1056-1058 |
| Date Published | 2018 12 |
| ISSN | 1546-1696 |
| Keywords | Cancer Vaccines, Cell Line, Tumor, Computer Simulation, Epitope Mapping, Epitopes, Humans, Introns, Models, Genetic, Neoplasms, RNA |
| Abstract | We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development. |
| DOI | 10.1038/nbt.4239 |
| Pubmed | |
| Alternate Journal | Nat. Biotechnol. |
| PubMed ID | 30114007 |
| PubMed Central ID | PMC6226333 |
| Grant List | K08 CA188615 / CA / NCI NIH HHS / United States R01 CA166480 / CA / NCI NIH HHS / United States R01 CA227388 / CA / NCI NIH HHS / United States |
Nat Biotechnol DOI:10.1038/nbt.4239
Intron retention is a source of neoepitopes in cancer.
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