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Tetrahedron letters DOI:10.1016/j.tetlet.2009.02.034

Aziridines as intermediates in diversity-oriented syntheses of alkaloids.

Publication TypeJournal Article
Year of Publication2009
AuthorsTaylor, AM, Schreiber, SL
JournalTetrahedron letters
Volume50
Issue26
Pages3230-3233
Date Published2009/07/02
ISSN0040-4039
Abstract

The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization.

DOI10.1016/j.tetlet.2009.02.034
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20046991?dopt=Abstract