A composite of multiple signals distinguishes causal variants in regions of positive selection.

Science
Authors
Keywords
Abstract

The human genome contains hundreds of regions whose patterns of genetic variation indicate recent positive natural selection, yet for most the underlying gene and the advantageous mutation remain unknown. We developed a method, composite of multiple signals (CMS), that combines tests for multiple signals of selection and increases resolution by up to 100-fold. By applying CMS to candidate regions from the International Haplotype Map, we localized population-specific selective signals to 55 kilobases (median), identifying known and novel causal variants. CMS can not just identify individual loci but implicates precise variants selected by evolution.

Year of Publication
2010
Journal
Science
Volume
327
Issue
5967
Pages
883-6
Date Published
2010 Feb 12
ISSN
1095-9203
URL
DOI
10.1126/science.1183863
PubMed ID
20056855
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