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Cold Spring Harb Perspect Biol DOI:10.1101/cshperspect.a003459

Nodal morphogens.

Publication TypeJournal Article
Year of Publication2009
AuthorsSchier, AF
JournalCold Spring Harb Perspect Biol
Volume1
Issue5
Pagesa003459
Date Published2009 Nov
ISSN1943-0264
KeywordsAnimals, Body Patterning, Diffusion, Endoderm, Humans, Kinetics, Left-Right Determination Factors, Mesoderm, MicroRNAs, Models, Biological, Morphogenesis, Nodal Protein, Protein Processing, Post-Translational, Signal Transduction, Transforming Growth Factor beta
Abstract

Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, coreceptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.

URLhttp://cshperspectives.cshlp.org/cgi/pmidlookup?view=long&pmid=20066122
DOI10.1101/cshperspect.a003459
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20066122?dopt=Abstract

Alternate JournalCold Spring Harb Perspect Biol
PubMed ID20066122
PubMed Central IDPMC2773646
Grant ListR01 GM056211 / GM / NIGMS NIH HHS / United States