Scientific Publications

Carbon metabolism-mediated myogenic differentiation.

Publication TypeJournal Article
AuthorsBracha, AL, Ramanathan A., Huang S., Ingber DE, and Schreiber SL
AbstractThe role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12 myoblasts even in the presence of mitogens. These enzymes and the pathways they regulate provide new targets for the control of myogenic differentiation in myoblasts and rhabdomyosarcoma cells.
Year of Publication2010
JournalNature chemical biology
Volume6
Issue3
Pages202-204
Date Published (YYYY/MM/DD)2010/03/01
ISSN Number1552-4450
DOI10.1038/nchembio.301
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20081855?dopt=Abstract