Scientific Publications

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.

Publication TypeJournal Article
AuthorsVerhaak, RG, Hoadley KA, Purdom E., Wang V., Qi Y., Wilkerson MD, Miller CR, Ding L., Golub T., Mesirov J. P., Alexe G., Lawrence M., O'Kelly M., Tamayo P., Weir BA, Gabriel S., Winckler W., Gupta S., Jakkula L., Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C., Kahn A., Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M., Getz G., Perou CM, Hayes DN, and Cancer Genome Atlas Research Network
AbstractThe Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
Year of Publication2010
JournalCancer cell
Volume17
Issue1
Pages98-110
Date Published (YYYY/MM/DD)2010/01/19
ISSN Number1535-6108
DOI10.1016/j.ccr.2009.12.020
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20129251?dopt=Abstract