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Stroke DOI:10.1161/STROKEAHA.109.563502

Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke.

Publication TypeJournal Article
Year of Publication2010
AuthorsJimenez-Conde, J, Biffi, A, Rahman, R, Kanakis, A, Butler, C, Sonni, S, Massasa, E, Cloonan, L, Gilson, A, Capozzo, K, Cortellini, L, Ois, A, Cuadrado-Godia, E, Rodriguez-Campello, A, Furie, KL, Roquer, J, Rosand, J, Rost, NS
Date Published2010 Mar
KeywordsAged, Aged, 80 and over, Brain Ischemia, Cohort Studies, Female, Humans, Hyperlipidemias, Male, Middle Aged, Nerve Fibers, Myelinated, Prospective Studies, Stroke

BACKGROUND AND PURPOSE: White matter hyperintensity (WMH), or leukoaraiosis, is a radiologic finding generally assumed to reflect diseased small cerebral vasculature. WMH has significant functional impact through its relation to cognitive decline and risk of ischemic and hemorrhagic stroke. Accumulating evidence suggests that some manifestations of small-vessel disease such as intracerebral hemorrhage are associated with low levels of cholesterol. We sought to determine the relation between hyperlipidemia and WMH severity in patients with acute ischemic stroke (AIS).

METHODS: We analyzed 2 independent, hospital-based AIS cohorts. Demographic and clinical data were collected prospectively. WMH was measured using semiautomated volumetric image analysis and a semiquantitative visual grading scale. Univariate and multivariable regression analyses were used to assess the relation between WMH severity and study variables.

RESULTS: A total of 631 and 504 subjects in the first and second cohorts, respectively, were included. In univariate analyses, advancing age and hypertension were associated with severity of WMH (P

CONCLUSIONS: Results from 2 independent cohorts demonstrate that AIS patients with a history of hyperlipidemia have less severe WMH at the time of stroke. These data support the hypothesis that hyperlipidemia may play a relatively protective role in cerebral small-vessel disease.


Alternate JournalStroke
PubMed ID20133919
PubMed Central IDPMC3787512
Grant ListK23 NS064052 / NS / NINDS NIH HHS / United States
K23NS42720 / NS / NINDS NIH HHS / United States
5P50NS051343 / NS / NINDS NIH HHS / United States
P50 NS051343 / NS / NINDS NIH HHS / United States
R01 NS04217 / NS / NINDS NIH HHS / United States