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Cell-based assays for high-throughput screening.
|Publication Type||Journal Article|
|Authors||An, WF, and Tolliday N.|
|Abstract||Cell-based assays represent approximately half of all high-throughput screens currently performed. Here, we review in brief the history and status of high-throughput screening (HTS), and summarize some of the challenges and benefits associated with the use of cell-based assays in HTS. Approaches for successful experimental design and execution of cell-based screens are introduced, including strategies for assay development, implementation of primary and secondary screens, and target identification. In doing so, we hope to provide a comprehensive review of the cell-based HTS process and an introduction to the methodologies and techniques used.|
|Year of Publication||2010|
|Date Published (YYYY/MM/DD)||2010/06/01|