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Mol Cell DOI:10.1016/j.molcel.2010.01.027

The fast track to multidrug resistance.

Publication TypeJournal Article
Year of Publication2010
AuthorsKaufmann, BB, Hung, DT
JournalMol Cell
Volume37
Issue3
Pages297-8
Date Published2010 Feb 12
ISSN1097-4164
KeywordsAnti-Bacterial Agents, Drug Resistance, Multiple, Bacterial, Escherichia coli, Gene Transfer, Horizontal, Microbial Sensitivity Tests, Mutagenesis
Abstract

In this issue of Molecular Cell, Kohanski et al. (2010) demonstrate that even subinhibitory concentrations of bactericidal antibiotics result in the generation of reactive oxygen species, leading to an increase in mutation rate and the emergence of multidrug-resistant bacterial strains.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1097-2765(10)00081-X
DOI10.1016/j.molcel.2010.01.027
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20159549?dopt=Abstract

Alternate JournalMol. Cell
PubMed ID20159549