Scientific Publications

The landscape of somatic copy-number alteration across human cancers.

Publication TypeJournal Article
AuthorsBeroukhim, R., Mermel CH, Porter D., Wei G., Raychaudhuri S., Donovan J., Barretina J., Boehm JS, Dobson J., Urashima M., Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L., Greulich H., Reich M., Winckler W., Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A., Hoffman C., Prensner J., Liefeld T., Gao Q., Yecies D., Signoretti S., Maher E., Kaye FJ, Sasaki H., Tepper JE, Fletcher JA, Tabernero J., Baselga J., Tsao MS, Demichelis F., Rubin MA, Janne PA, Daly M. J., Nucera C., Levine RL, Ebert BL, Gabriel S., Rustgi AK, Antonescu CR, Ladanyi M., Letai A., Garraway LA, Loda M., Beer DG, True LD, Okamoto A., Pomeroy SL, Singer S., Golub T. R., Lander E. S., Getz G., Sellers WR, and Meyerson M.
AbstractA powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-kappaBeta pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types.
Year of Publication2010
JournalNature
Volume463
Issue7283
Pages899-905
Date Published (YYYY/MM/DD)2010/02/18
ISSN Number0028-0836
DOI10.1038/nature08822
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20164920?dopt=Abstract