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Bioinformatics (Oxford, England) DOI:10.1093/bioinformatics/btq102

Genome-wide synteny through highly sensitive sequence alignment: Satsuma.

Publication TypeJournal Article
Year of Publication2010
AuthorsGrabherr, MG, Russell, P, Meyer, M, Mauceli, E, Alföldi, J, Di Palma, F, Lindblad-Toh, K
JournalBioinformatics (Oxford, England)
Volume26
Issue9
Pages1145-51
Date Published2010/05/01
ISSN1367-4803
Abstract

Comparative genomics heavily relies on alignments of large and often complex DNA sequences. From an engineering perspective, the problem here is to provide maximum sensitivity (to find all there is to find), specificity (to only find real homology) and speed (to accommodate the billions of base pairs of vertebrate genomes).

URLhttp://bioinformatics.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=20208069
DOI10.1093/bioinformatics/btq102
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20208069?dopt=Abstract