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Curr Opin Cardiol DOI:10.1097/HCO.0b013e3283383e2c

Blood pressure and human genetic variation in the general population.

Publication TypeJournal Article
Year of Publication2010
AuthorsArora, P, Newton-Cheh, C
JournalCurr Opin Cardiol
Volume25
Issue3
Pages229-37
Date Published2010 May
ISSN1531-7080
KeywordsBlood Pressure, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Hypertension, Mutation
Abstract

PURPOSE OF REVIEW: Hypertension is a complex trait with multiple environmental and genetic contributors. Until recently, linkage studies of rare Mendelian disorders of hypertension and hypotension have produced the most notable progress toward understanding the heritable basis of blood pressure (BP). Association studies to identify common variants have been limited in the past by small sample sizes and most findings have lacked replication.

RECENT FINDINGS: Recently, well powered, targeted candidate gene and genome-wide association studies have reported reproducible associations between rare and common genetic variants and BP and hypertension at the population level.

SUMMARY: Identification of novel genes will lead to an improved understanding of BP regulation and the potential for novel therapies.

URLhttp://dx.doi.org/10.1097/HCO.0b013e3283383e2c
DOI10.1097/HCO.0b013e3283383e2c
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20224392?dopt=Abstract

Alternate JournalCurr. Opin. Cardiol.
PubMed ID20224392
PubMed Central IDPMC2947583
Grant ListK23 HL080025-05 / HL / NHLBI NIH HHS / United States
K23-HL080025 / HL / NHLBI NIH HHS / United States
R01 HL098283 / HL / NHLBI NIH HHS / United States
R01-HL098283 / HL / NHLBI NIH HHS / United States
K23 HL080025 / HL / NHLBI NIH HHS / United States