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Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.
|Publication Type||Journal Article|
|Authors||Stanley, SA, and Hung DT|
|Abstract||Loss-of-function genetic screens have facilitated great strides in our understanding of the biology of model organisms but have not been possible in diploid human cells. A recent report by Brummelkamp's group in Science describes the use of insertional mutagenesis to generate loss-of-function alleles in a largely haploid human cell line and demonstrates the versatility of this method in screens designed to investigate the host/pathogen interaction. This approach has strengths that are complementary to existing strategies and will facilitate progress toward a systems-level understanding of infectious disease and ultimately the development of new therapeutics.|
|Year of Publication||2009|
|Journal||Science translational medicine|
|Date Published (YYYY/MM/DD)||2009/12/16|