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Nature DOI:10.1038/nature08987

International network of cancer genome projects.

Publication TypeJournal Article
Year of Publication2010
AuthorsHudson, TJ, Anderson, W, Artez, A, Barker, AD, Bell, C, Bernabé, RR, Bhan, MK, Calvo, F, Eerola, I, Gerhard, DS, Guttmacher, A, Guyer, M, Hemsley, FM, Jennings, JL, Kerr, D, Klatt, P, Kolar, P, Kusada, J, Lane, DP, Laplace, F, Youyong, L, Nettekoven, G, Ozenberger, B, Peterson, J, Rao, TS, Remacle, J, Schafer, AJ, Shibata, T, Stratton, MR, Vockley, JG, Watanabe, K, Yang, H, Yuen, MMF, Knoppers, BM, Bobrow, M, Cambon-Thomsen, A, Dressler, LG, Dyke, SOM, Joly, Y, Kato, K, Kennedy, KL, Nicolás, P, Parker, MJ, Rial-Sebbag, E, Romeo-Casabona, CM, Shaw, KM, Wallace, S, Wiesner, GL, Zeps, N, Lichter, P, Biankin, AV, Chabannon, C, Chin, L, Clément, B, de Alava, E, Degos, F, Ferguson, ML, Geary, P, D Hayes, N, Hudson, TJ, Johns, AL, Kasprzyk, A, Nakagawa, H, Penny, R, Piris, MA, Sarin, iv, R, Scarpa, A, Shibata, T, van de Vijver, M, P Futreal, A, Aburatani, H, Bayés, M, Botwell, DDL, Campbell, PJ, Estivill, X, Gerhard, DS, Grimmond, SM, Gut, I, Hirst, M, López-Otín, C, Majumder, P, Marra, M, McPherson, JD, Nakagawa, H, Ning, Z, Puente, XS, Ruan, Y, Shibata, T, Stratton, MR, Stunnenberg, HG, Swerdlow, H, Velculescu, VE, Wilson, RK, Xue, HH, Yang, L, Spellman, PT, Bader, GD, Boutros, PC, Campbell, PJ, Flicek, P, Getz, G, Guigo, R, Guo, G, Haussler, D, Heath, S, Hubbard, TJ, Jiang, T, Jones, SM, Li, Q, López-Bigas, N, Luo, R, Muthuswamy, L, Ouellette, BFFrancis, Pearson, JV, Puente, XS, Quesada, V, Raphael, BJ, Sander, C, Shibata, T, Speed, TP, Stein, LD, Stuart, JM, Teague, JW, Totoki, Y, Tsunoda, T, Valencia, A, Wheeler, DA, Wu, H, Zhao, S, Zhou, G, Stein, LD, Guigo, R, Hubbard, TJ, Joly, Y, Jones, SM, Kasprzyk, A, Lathrop, M, López-Bigas, N, Ouellette, BFFrancis, Spellman, PT, Teague, JW, Thomas, G, Valencia, A, Yoshida, T, Kennedy, KL, Axton, M, Dyke, SOM, P Futreal, A, Gerhard, DS, Gunter, C, Guyer, M, Hudson, TJ, McPherson, JD, Miller, LJ, Ozenberger, B, Shaw, KM, Kasprzyk, A, Stein, LD, Zhang, J, Haider, SA, Wang, J, Yung, CK, Cros, A, Cross, A, Liang, Y, Gnaneshan, S, Guberman, J, Hsu, J, Bobrow, M, Chalmers, DRC, Hasel, KW, Joly, Y, Kaan, TSH, Kennedy, KL, Knoppers, BM, Lowrance, WW, Masui, T, Nicolás, P, Rial-Sebbag, E, Rodriguez, LLyman, Vergely, C, Yoshida, T, Grimmond, SM, Biankin, AV, Bowtell, DDL, Cloonan, N, deFazio, A, Eshleman, JR, Etemadmoghadam, D, Gardiner, BB, Gardiner, BA, Kench, JG, Scarpa, A, Sutherland, RL, Tempero, MA, Waddell, NJ, Wilson, PJ, McPherson, JD, Gallinger, S, Tsao, M-S, Shaw, PA, Petersen, GM, Mukhopadhyay, D, Chin, L, DePinho, RA, Thayer, S, Muthuswamy, L, Shazand, K, Beck, T, Sam, M, Timms, L, Ballin, V, Lu, Y, Ji, J, Zhang, X, Chen, F, Hu, X, Zhou, G, Yang, Q, Tian, G, Zhang, L, Xing, X, Li, X, Zhu, Z, Yu, Y, Yu, J, Yang, H, Lathrop, M, Tost, J, Brennan, P, Holcatova, I, Zaridze, D, Brazma, A, Egevard, L, Prokhortchouk, E, Banks, RElizabeth, Uhlen, M, Cambon-Thomsen, A, Viksna, J, Ponten, F, Skryabin, K, Stratton, MR, P Futreal, A, Birney, E, Borg, A, Børresen-Dale, A-L, Caldas, C, Foekens, JA, Martin, S, Reis-Filho, JS, Richardson, AL, Sotiriou, C, Stunnenberg, HG, Thoms, G, van de Vijver, M, Veer, Lvan't, Calvo, F, Birnbaum, D, Blanche, H, Boucher, P, Boyault, S, Chabannon, C, Gut, I, Masson-Jacquemier, JD, Lathrop, M, Pauporté, I, Pivot, X, Vincent-Salomon, A, Tabone, E, Theillet, C, Thomas, G, Tost, J, Treilleux, I, Calvo, F, Bioulac-Sage, P, Clément, B, Decaens, T, Degos, F, Franco, D, Gut, I, Gut, M, Heath, S, Lathrop, M, Samuel, D, Thomas, G, Zucman-Rossi, J, Lichter, P, Eils, R, Brors, B, Korbel, JO, Korshunov, A, Landgraf, P, Lehrach, H, Pfister, S, Radlwimmer, B, Reifenberger, G, Taylor, MD, von Kalle, C, Majumder, PP, Sarin, iv, R, Rao, TS, Bhan, MK, Scarpa, A, Pederzoli, P, Lawlor, RA, Delledonne, M, Bardelli, A, Biankin, AV, Grimmond, SM, Gress, T, Klimstra, D, Zamboni, G, Shibata, T, Nakamura, Y, Nakagawa, H, Kusada, J, Tsunoda, T, Miyano, S, Aburatani, H, Kato, K, Fujimoto, A, Yoshida, T, Campo, E, López-Otín, C, Estivill, X, Guigo, R, de Sanjosé, S, Piris, MA, Montserrat, E, González-Díaz, M, Puente, XS, Jares, P, Valencia, A, Himmelbauer, H, Himmelbaue, H, Quesada, V, Bea, S, Stratton, MR, P Futreal, A, Campbell, PJ, Vincent-Salomon, A, Richardson, AL, Reis-Filho, JS, van de Vijver, M, Thomas, G, Masson-Jacquemier, JD, Aparicio, S, Borg, A, Børresen-Dale, A-L, Caldas, C, Foekens, JA, Stunnenberg, HG, Veer, Lvan't, Easton, DF, Spellman, PT, Martin, S, Barker, AD, Chin, L, Collins, FS, Compton, CC, Ferguson, ML, Gerhard, DS, Getz, G, Gunter, C, Guttmacher, A, Guyer, M, D Hayes, N, Lander, ES, Ozenberger, B, Penny, R, Peterson, J, Sander, C, Shaw, KM, Speed, TP, Spellman, PT, Vockley, JG, Wheeler, DA, Wilson, RK, Hudson, TJ, Chin, L, Knoppers, BM, Lander, ES, Lichter, P, Stein, LD, Stratton, MR, Anderson, W, Barker, AD, Bell, C, Bobrow, M, Burke, W, Collins, FS, Compton, CC, DePinho, RA, Easton, DF, P Futreal, A, Gerhard, DS, Green, AR, Guyer, M, Hamilton, SR, Hubbard, TJ, Kallioniemi, OP, Kennedy, KL, Ley, TJ, Liu, ET, Lu, Y, Majumder, P, Marra, M, Ozenberger, B, Peterson, J, Schafer, AJ, Spellman, PT, Stunnenberg, HG, Wainwright, BJ, Wilson, RK, Yang, H
Corporate AuthorsInternational Cancer Genome Consortium
JournalNature
Volume464
Issue7291
Pages993-8
Date Published2010 Apr 15
ISSN1476-4687
KeywordsDatabases, Genetic, DNA Methylation, DNA Mutational Analysis, Genes, Neoplasm, Genetics, Medical, Genome, Human, Genomics, Humans, Intellectual Property, International Cooperation, Mutation, Neoplasms
Abstract

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

URLhttp://dx.doi.org/10.1038/nature08987
DOI10.1038/nature08987
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20393554?dopt=Abstract

Alternate JournalNature
PubMed ID20393554
PubMed Central IDPMC2902243
Grant ListP50 CA127003-05 / CA / NCI NIH HHS / United States
P50 CA102701-08 / CA / NCI NIH HHS / United States
R01 HG001806-02 / HG / NHGRI NIH HHS / United States
P01 CA117969 / CA / NCI NIH HHS / United States
K08 DK071329 / DK / NIDDK NIH HHS / United States
088340 / / Wellcome Trust / United Kingdom
K08 DK071329-05 / DK / NIDDK NIH HHS / United States
P50 CA127003-04 / CA / NCI NIH HHS / United States
093867 / / Wellcome Trust / United Kingdom
P50 CA102701 / CA / NCI NIH HHS / United States
R21 CA094510 / CA / NCI NIH HHS / United States
K08 DK071329-04 / DK / NIDDK NIH HHS / United States
077198 / / Wellcome Trust / United Kingdom
P50 CA127003 / CA / NCI NIH HHS / United States
P01 CA117969-05 / CA / NCI NIH HHS / United States
P01 CA117969-04S1 / CA / NCI NIH HHS / United States