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Circulation. Cardiovascular genetics DOI:10.1161/CIRCGENETICS.109.882696

Candidate gene association resource (CARe): design, methods, and proof of concept.

Publication TypeJournal Article
Year of Publication2010
AuthorsMusunuru, K, Lettre, G, Young, T, Farlow, DN, Pirruccello, JP, Ejebe, KG, Keating, BJ, Yang, Q, Chen, MH, Lapchyk, N, Crenshaw, A, Ziaugra, L, Rachupka, A, Benjamin, EJ, Cupples, LA, Fornage, M, Fox, ER, Heckbert, SR, Hirschhorn, JN, Newton-Cheh, C, Nizzari, MM, Paltoo, DN, Papanicolaou, GJ, Patel, SR, Psaty, BM, Rader, DJ, Redline, S, Rich, SS, Rotter, JI, Taylor HA, J, Tracy, RP, Vasan, RS, Wilson, JG, Kathiresan, S, Fabsitz, RR, Boerwinkle, E, Gabriel, SB, NHLBI Candidate Gene Association, R
JournalCirculation. Cardiovascular genetics
Date Published2010/06/01

The National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe), a planned cross-cohort analysis of genetic variation in cardiovascular, pulmonary, hematologic, and sleep-related traits, comprises >40,000 participants representing 4 ethnic groups in 9 community-based cohorts. The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans.