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Curr Opin Chem Biol DOI:10.1016/j.cbpa.2010.03.018

Current strategies for diversity-oriented synthesis.

Publication TypeJournal Article
Year of Publication2010
AuthorsDandapani, S, Marcaurelle, LA
JournalCurr Opin Chem Biol
Volume14
Issue3
Pages362-70
Date Published2010 Jun
ISSN1879-0402
KeywordsChemical Phenomena, Drug Discovery, Models, Chemical, Small Molecule Libraries
Abstract

Compounds accessed through diversity-oriented synthesis (DOS) are showing promise in modulating the activities of several targets that are currently considered 'undruggable'. Recently many new DOS pathways have been developed employing multi-component reactions, cycloadditions, ring-closing metathesis and tandem processes. Functional group pairing and 'build/couple/pair' strategies have been described as a means for generating structural diversity. Efforts have also been directed towards developing DOS libraries based on privileged scaffolds. Recent studies have provided several compelling examples for the utility of DOS compounds for producing novel biological probes and application of DOS in the context of drug discovery is extremely appealing.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1367-5931(10)00044-X
DOI10.1016/j.cbpa.2010.03.018
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20409744?dopt=Abstract

Alternate JournalCurr Opin Chem Biol
PubMed ID20409744
Grant ListP50 GM069721 / GM / NIGMS NIH HHS / United States