Scientific Publications

A survey of sequence alignment algorithms for next-generation sequencing.

Publication TypeJournal Article
AuthorsLi, H., and Homer N.
AbstractRapidly evolving sequencing technologies produce data on an unparalleled scale. A central challenge to the analysis of this data is sequence alignment, whereby sequence reads must be compared to a reference. A wide variety of alignment algorithms and software have been subsequently developed over the past two years. In this article, we will systematically review the current development of these algorithms and introduce their practical applications on different types of experimental data. We come to the conclusion that short-read alignment is no longer the bottleneck of data analyses. We also consider future development of alignment algorithms with respect to emerging long sequence reads and the prospect of cloud computing.
Year of Publication2010
JournalBriefings in bioinformatics
Volume11
Issue5
Pages473-83
Date Published (YYYY/MM/DD)2010/09/01
ISSN Number1467-5463
DOI10.1093/bib/bbq015
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20460430?dopt=Abstract