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Organic letters DOI:10.1021/ol100914b

Stereochemical and skeletal diversity arising from amino propargylic alcohols.

Publication TypeJournal Article
Year of Publication2010
AuthorsPizzirani, D, Kaya, T, Clemons, PA, Schreiber, SL
JournalOrganic letters
Volume12
Issue12
Pages2822-5
Date Published2010/06/18
ISSN1523-7060
Abstract

An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.

URLhttp://dx.doi.org/10.1021/ol100914b
DOI10.1021/ol100914b
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20481457?dopt=Abstract