Distinct biological network properties between the targets of natural products and disease genes.

J Am Chem Soc
Authors
Keywords
Abstract

We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.

Year of Publication
2010
Journal
J Am Chem Soc
Volume
132
Issue
27
Pages
9259-61
Date Published
2010 Jul 14
ISSN
1520-5126
URL
DOI
10.1021/ja102798t
PubMed ID
20565092
PubMed Central ID
PMC2898216
Links
Grant list
P50-GM069721 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States
P50 GM069721 / GM / NIGMS NIH HHS / United States
RL1-HG004671 / HG / NHGRI NIH HHS / United States
RL1 HG004671 / HG / NHGRI NIH HHS / United States