Scientific Publications

Distinct biological network properties between the targets of natural products and disease genes.

Publication TypeJournal Article
AuthorsDancík, V., Seiler KP, Young DW, Schreiber SL, and Clemons PA
AbstractWe show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.
Year of Publication2010
JournalJournal of the American Chemical Society
Volume132
Issue27
Pages9259-61
Date Published (YYYY/MM/DD)2010/07/14
ISSN Number0002-7863
DOI10.1021/ja102798t
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20565092?dopt=Abstract