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J Am Chem Soc DOI:10.1021/ja102798t

Distinct biological network properties between the targets of natural products and disease genes.

Publication TypeJournal Article
Year of Publication2010
AuthorsDančík, V, Seiler, KPetri, Young, DW, Schreiber, SL, Clemons, PA
JournalJ Am Chem Soc
Volume132
Issue27
Pages9259-61
Date Published2010 Jul 14
ISSN1520-5126
KeywordsBiological Products, Disease, Drug Delivery Systems, Drug Design, Humans, Protein Binding, Proteins, Systems Biology
Abstract

We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.

URLhttp://dx.doi.org/10.1021/ja102798t
DOI10.1021/ja102798t
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20565092?dopt=Abstract

Alternate JournalJ. Am. Chem. Soc.
PubMed ID20565092
PubMed Central IDPMC2898216
Grant ListP50-GM069721 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
P50 GM069721 / GM / NIGMS NIH HHS / United States
RL1-HG004671 / HG / NHGRI NIH HHS / United States
RL1 HG004671 / HG / NHGRI NIH HHS / United States