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Nat Genet DOI:10.1038/ng.609

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Publication TypeJournal Article
Year of Publication2010
AuthorsVoight, BF, Scott, LJ, Steinthorsdottir, V, Morris, AP, Dina, C, Welch, RP, Zeggini, E, Huth, C, Aulchenko, YS, Thorleifsson, G, McCulloch, LJ, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, CJ, Raychaudhuri, S, McCarroll, SA, Langenberg, C, Hofmann, OM, Dupuis, J, Qi, L, Segrè, AV, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, AJ, Blagieva, R, Boerwinkle, E, Bonnycastle, LL, Boström, KBengtsson, Bravenboer, B, Bumpstead, S, Burtt, NP, Charpentier, G, Chines, PS, Cornelis, M, Couper, DJ, Crawford, G, Doney, ASF, Elliott, KS, Elliott, AL, Erdos, MR, Fox, CS, Franklin, CS, Ganser, M, Gieger, C, Grarup, N, Green, T, Griffin, S, Groves, CJ, Guiducci, C, Hadjadj, S, Hassanali, N, Herder, C, Isomaa, B, Jackson, AU, Johnson, PRV, Jørgensen, T, Kao, WHL, Klopp, N, Kong, A, Kraft, P, Kuusisto, J, Lauritzen, T, Li, M, Lieverse, A, Lindgren, CM, Lyssenko, V, Marre, M, Meitinger, T, Midthjell, K, Morken, MA, Narisu, N, Nilsson, P, Owen, KR, Payne, F, Perry, JRB, Petersen, A-K, Platou, C, Proença, C, Prokopenko, I, Rathmann, W, N Rayner, W, Robertson, NR, Rocheleau, G, Roden, M, Sampson, MJ, Saxena, R, Shields, BM, Shrader, P, Sigurdsson, G, Sparsø, T, Strassburger, K, Stringham, HM, Sun, Q, Swift, AJ, Thorand, B, Tichet, J, Tuomi, T, van Dam, RM, van Haeften, TW, van Herpt, T, van Vliet-Ostaptchouk, JV, G Walters, B, Weedon, MN, Wijmenga, C, Witteman, J, Bergman, RN, Cauchi, S, Collins, FS, Gloyn, AL, Gyllensten, U, Hansen, T, Hide, WA, Hitman, GA, Hofman, A, Hunter, DJ, Hveem, K, Laakso, M, Mohlke, KL, Morris, AD, Palmer, CNA, Pramstaller, PP, Rudan, I, Sijbrands, E, Stein, LD, Tuomilehto, J, Uitterlinden, A, Walker, M, Wareham, NJ, Watanabe, RM, Abecasis, GR, Boehm, BO, Campbell, H, Daly, MJ, Hattersley, AT, Hu, FB, Meigs, JB, Pankow, JS, Pedersen, O, Wichmann, H-E, Barroso, I, Florez, JC, Frayling, TM, Groop, L, Sladek, R, Thorsteinsdottir, U, Wilson, JF, Illig, T, Froguel, P, van Duijn, CM, Stefansson, K, Altshuler, D, Boehnke, M, McCarthy, MI
Corporate AuthorsMAGIC Investigators, GIANT Consortium
JournalNat Genet
Volume42
Issue7
Pages579-89
Date Published2010 Jul
ISSN1546-1718
KeywordsBlood Glucose, Diabetes Mellitus, Type 2, Dual-Specificity Phosphatases, Fasting, Gene Dosage, Gene Expression Profiling, Genetic Heterogeneity, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Hepatocyte Nuclear Factor 1-alpha, Humans, KCNQ1 Potassium Channel, Meta-Analysis as Topic, Mitogen-Activated Protein Kinase Phosphatases, Polymorphism, Single Nucleotide
Abstract

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P

URLhttp://dx.doi.org/10.1038/ng.609
DOI10.1038/ng.609
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20581827?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID20581827
PubMed Central IDPMC3080658
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
CZB/4/710 / / Chief Scientist Office / United Kingdom
R01 DK073490 / DK / NIDDK NIH HHS / United States
K08 AR055688-03 / AR / NIAMS NIH HHS / United States
R01 DK058845 / DK / NIDDK NIH HHS / United States
R56 DK062370 / DK / NIDDK NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
G0600331 / / Medical Research Council / United Kingdom
079557 / / Wellcome Trust / United Kingdom
R01HL59367 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
086596 / / Wellcome Trust / United Kingdom
N01-HC-55022 / HC / NHLBI NIH HHS / United States
088885 / / Wellcome Trust / United Kingdom
R01 HL059367 / HL / NHLBI NIH HHS / United States
K23-DK65978 / DK / NIDDK NIH HHS / United States
G0700222(81696) / / Medical Research Council / United Kingdom
N01-HC-55016 / HC / NHLBI NIH HHS / United States
U01 HG004171 / HG / NHGRI NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
DK58845 / DK / NIDDK NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
DK069922 / DK / NIDDK NIH HHS / United States
U01HG004399 / HG / NHGRI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
075491 / / Wellcome Trust / United Kingdom
DHCS/07/07/008 / / Department of Health / United Kingdom
N01HC55015 / HL / NHLBI NIH HHS / United States
077016 / / Wellcome Trust / United Kingdom
1K08AR055688 / AR / NIAMS NIH HHS / United States
083270 / / Wellcome Trust / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
072960 / / Wellcome Trust / United Kingdom
K99 HL094535 / HL / NHLBI NIH HHS / United States
DK072193 / DK / NIDDK NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
076113 / / Wellcome Trust / United Kingdom
K24-DK080140 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
R01 DK029867 / DK / NIDDK NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
G0701863 / / Medical Research Council / United Kingdom
K24 DK080140 / DK / NIDDK NIH HHS / United States
090532 / / Wellcome Trust / United Kingdom
N01-HC-55020 / HC / NHLBI NIH HHS / United States
U01HG004171 / HG / NHGRI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
MC_U106179474 / / Medical Research Council / United Kingdom
U01 DK078616 / DK / NIDDK NIH HHS / United States
1K99HL094535-01A1 / HL / NHLBI NIH HHS / United States
DK078616 / DK / NIDDK NIH HHS / United States
G0700222 / / Medical Research Council / United Kingdom
064890 / / Wellcome Trust / United Kingdom
U01 DK062370 / DK / NIDDK NIH HHS / United States
DK062370 / DK / NIDDK NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
Z01 HG000024 / HG / NHGRI NIH HHS / United States
MC_U127592696 / / Medical Research Council / United Kingdom
K08 AR055688 / AR / NIAMS NIH HHS / United States
U54 DA021519 / DA / NIDA NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
DK073490 / DK / NIDDK NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
G0601261 / / Medical Research Council / United Kingdom
U01 HG004399 / HG / NHGRI NIH HHS / United States
K23 DK065978 / DK / NIDDK NIH HHS / United States
R01 DK069922 / DK / NIDDK NIH HHS / United States
081682 / / Wellcome Trust / United Kingdom
R01HL086694 / HL / NHLBI NIH HHS / United States