Lipid Droplet Biogenesis.

Annu Rev Cell Dev Biol

Authors	Tobias Walther Jeeyun Chung Robert Farese
Keywords	Animals Humans Triglycerides Proteins Models, Biological Lipid Droplets Biophysical Phenomena
Abstract	Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis. We present a model of LD formation from the ER in distinct steps and highlight the biology of proteins that govern this biophysical process. Areas of incomplete knowledge are identified, as are connections with physiology and diseases linked to alterations in LD biology.
Year of Publication	2017
Journal	Annu Rev Cell Dev Biol
Volume	33
Pages	491-510
Date Published	2017 10 06
ISSN	1530-8995
DOI	10.1146/annurev-cellbio-100616-060608
PubMed ID	28793795
Links	PubMed Google Scholar DOI
Grant list	R01 DK101579 / DK / NIDDK NIH HHS / United States R01 DK056084 / DK / NIDDK NIH HHS / United States R01 GM097194 / GM / NIGMS NIH HHS / United States HHMI / Howard Hughes Medical Institute / United States

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