|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Urgaonkar, S, Cortese, JF, Barker, RH, Cromwell, M, Serrano, AE, Wirth, DF, Clardy, J, Mazitschek, R|
The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps and in good yields via oxoindole intermediates by employing tert-butyldimethylsilyl amine (TBDMSNH(2)) as previously unexplored ammonia equivalent.