Scientific Publications

Large non-coding RNAs: missing links in cancer?

Publication TypeJournal Article
AuthorsHuarte, M., and Rinn JL
AbstractCellular homeostasis is achieved by the proper balance of regulatory networks that if disrupted can lead to cellular transformation. These cell circuits are fine-tuned and maintained by the coordinated function of proteins and non-coding RNAs (ncRNAs). In addition to the well-characterized protein coding and microRNAs constituents, large ncRNAs are also emerging as important regulatory molecules in tumor-suppressor and oncogenic pathways. Recent studies have revealed mechanistic insight of large ncRNAs regulating key cancer pathways at a transcriptional, post-transcriptional and epigenetic level. Here we synthesize these latest advances within the context of their mechanistic roles in regulating and maintaining cellular equilibrium. We posit that similar to protein-coding genes, large ncRNAs are a newly emerging class of oncogenic and tumor-suppressor genes. Our growing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potential use as biomarkers and targets for novel therapeutic approaches in the future.
Year of Publication2010
JournalHuman molecular genetics
Volume19
IssueR2
PagesR152-61
Date Published (YYYY/MM/DD)2010/10/15
ISSN Number0964-6906
DOI10.1093/hmg/ddq353
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20729297?dopt=Abstract