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Organic letters DOI:10.1021/ol102266j

Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.

Publication TypeJournal Article
Year of Publication2010
AuthorsMuncipinto, G, Kaya, T, Wilson, JA, Kumagai, N, Clemons, PA, Schreiber, SL
JournalOrganic letters
Volume12
Issue22
Pages5230-3
Date Published2010/11/19
ISSN1523-7060
Abstract

A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and isoxazolidines is described. The change in shape of previous compounds and those in this study is quantified and compared using principal moment-of-inertia shape analysis.

URLhttp://dx.doi.org/10.1021/ol102266j
DOI10.1021/ol102266j
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20977261?dopt=Abstract