Scientific Publications

Nearest template prediction: a single-sample-based flexible class prediction with confidence assessment.

Publication TypeJournal Article
AuthorsHoshida, Y.
AbstractGene-expression signature-based disease classification and clinical outcome prediction has not been widely introduced in clinical medicine as initially expected, mainly due to the lack of extensive validation needed for its clinical deployment. Obstacles include variable measurement in microarray assay, inconsistent assay platform, analytical requirement for comparable pair of training and test datasets, etc. Furthermore, as medical device helping clinical decision making, the prediction needs to be made for each single patient with a measure of its reliability. To address these issues, there is a need for flexible prediction method less sensitive to difference in experimental and analytical conditions, applicable to each single patient, and providing measure of prediction confidence. The nearest template prediction (NTP) method provides a convenient way to make class prediction with assessment of prediction confidence computed in each single patient's gene-expression data using only a list of signature genes and a test dataset. We demonstrate that the method can be flexibly applied to cross-platform, cross-species, and multiclass predictions without any optimization of analysis parameters.
Year of Publication2010
JournalPloS one
Volume5
Issue11
Pagese15543
Date Published (YYYY/MM/DD)2010/11/23
DOI10.1371/journal.pone.0015543
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21124904?dopt=Abstract