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Curr Opin Neurobiol DOI:10.1016/j.conb.2017.03.010

Animal models for neuropsychiatric disorders: prospects for circuit intervention.

Publication TypeJournal Article
Year of Publication2017
AuthorsKaiser, T, Zhou, Y, Feng, G
JournalCurr Opin Neurobiol
Date Published2017 08
KeywordsAnimals, Disease Models, Animal, Mental Disorders, Nervous System Diseases, Neuropsychiatry, Phenotype

Monogenic animal models for psychiatric diseases have enabled researchers to dissect the relationship between certain candidate genes, neural circuit abnormalities, and behavioral phenotypes along development. Early reports of phenotypic reversal after genetic restoration in mouse models sparked hope that genetic defects do not damage circuits irreversibly in early-onset disorders. However, further studies have suggested that only some circuits exhibit this plasticity, while many others require proper gene function during development. This review focuses on what we have learned from a few evolutionarily conserved circuit-phenotype relationships and their developmental windows to illustrate their importance when considering intervention strategies.


Alternate JournalCurr. Opin. Neurobiol.
PubMed ID28419975