Scientific Publications

Application of a sparse matrix design strategy to the synthesis of dos libraries.

Publication TypeJournal Article
AuthorsAkella, LB, and Marcaurelle LA
AbstractWe have implemented an interactive and practical sparse matrix design strategy for the synthesis of DOS libraries, which facilitates the selection of diverse library members within a user-defined range of physicochemical properties while still maintaining synthetic efficiency. The utility of this approach is illustrated with the synthesis of an 8000-membered library of stereochemically diverse medium-sized rings accessible via a build/couple/pair DOS strategy. Diverse library members were selected from a virtual library by applying the maximum dissimilarity method, while the selection of similar analogs around each diverse product was ensured by picking near neighbors algorithmically based on fingerprint comparison. Adjustable filters on compound properties, which can be tailored to suit the needs of the target biology, facilitated subset selection from the synthetically accessible compounds.
Year of Publication2011
JournalACS combinatorial science
Volume13
Issue4
Pages357-64
Date Published (YYYY/MM/DD)2011/07/11
ISSN Number2156-8952
DOI10.1021/co200020j
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21526822?dopt=Abstract