Scientific Publications

mRNA expression signature of Gleason grade predicts lethal prostate cancer.

Publication TypeJournal Article
AuthorsPenney, KL, Sinnott JA, Fall K., Pawitan Y., Hoshida Y., Kraft P., Stark JR, Fiorentino M., Perner S., Finn S., Calza S., Flavin R., Freedman ML, Setlur S., Sesso HD, Andersson SO, Martin N., Kantoff PW, Johansson JE, Adami HO, Rubin MA, Loda M., Golub T. R., Andrén O., Stampfer MJ, and Mucci LA
AbstractProstate-specific antigen screening has led to enormous overtreatment of prostate cancer because of the inability to distinguish potentially lethal disease at diagnosis. We reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors, the most common grade, and the most indeterminate in terms of prognosis.
Year of Publication2011
JournalJournal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume29
Issue17
Pages2391-6
Date Published (YYYY/MM/DD)2011/06/10
ISSN Number0732-183X
DOI10.1200/JCO.2010.32.6421
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21537050?dopt=Abstract