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The Journal of infectious diseases DOI:10.1093/infdis/jir303

Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

Publication TypeJournal Article
Year of Publication2011
AuthorsPeng, LF, Schaefer, EA, Maloof, N, Skaff, A, Berical, A, Belon, CA, Heck, JA, Lin, W, Frick, DN, Allen, TM, Miziorko, HM, Schreiber, SL, Chung, RT
JournalThe Journal of infectious diseases
Volume204
Issue4
Pages609-16
Date Published2011/08/15
ISSN0022-1899
Abstract

Hepatitis C virus (HCV) chronically infects >170 million persons worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. The identification of more effective and better-tolerated agents for treating HCV is a high priority. We have reported elsewhere the discovery of the anti-HCV compound ceestatin using a high-throughput screen of a small molecule library.

URLhttp://www.jid.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=21791663
DOI10.1093/infdis/jir303
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21791663?dopt=Abstract