|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Dandapani, S, Lowe, JT, Comer, E, Marcaurelle, LA|
|Journal||The Journal of organic chemistry|
An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.