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The Journal of organic chemistry DOI:10.1021/jo2011957

Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

Publication TypeJournal Article
Year of Publication2011
AuthorsDandapani, S, Lowe, JT, Comer, E, Marcaurelle, LA
JournalThe Journal of organic chemistry
Volume76
Issue19
Pages8042-8
Date Published2011/10/07
ISSN0022-3263
Abstract

An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.

URLhttp://dx.doi.org/10.1021/jo2011957
DOI10.1021/jo2011957
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21875084?dopt=Abstract