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Bioinformatics (Oxford, England) DOI:10.1093/bioinformatics/btr509

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.

Publication TypeJournal Article
Year of Publication2011
AuthorsLi, H
JournalBioinformatics (Oxford, England)
Volume27
Issue21
Pages2987-93
Date Published2011/11/01
ISSN1367-4803
Abstract

Most existing methods for DNA sequence analysis rely on accurate sequences or genotypes. However, in applications of the next-generation sequencing (NGS), accurate genotypes may not be easily obtained (e.g. multi-sample low-coverage sequencing or somatic mutation discovery). These applications press for the development of new methods for analyzing sequence data with uncertainty.

URLhttp://bioinformatics.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=21903627
DOI10.1093/bioinformatics/btr509
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21903627?dopt=Abstract