The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.
Cell Metab
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Abstract | The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors. |
Year of Publication | 2017
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Journal | Cell Metab
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Volume | 26
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Issue | 2
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Pages | 301-309
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Date Published | 2017 Aug 01
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ISSN | 1932-7420
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DOI | 10.1016/j.cmet.2017.07.001
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PubMed ID | 28768171
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PubMed Central ID | PMC5560103
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Grant list | R01 AI047389 / AI / NIAID NIH HHS / United States
R01 CA103866 / CA / NCI NIH HHS / United States
F30 CA189333 / CA / NCI NIH HHS / United States
T32 GM007753 / GM / NIGMS NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States
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