The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

Cell Metab
Authors
Keywords
Abstract

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.

Year of Publication
2017
Journal
Cell Metab
Volume
26
Issue
2
Pages
301-309
Date Published
2017 Aug 01
ISSN
1932-7420
DOI
10.1016/j.cmet.2017.07.001
PubMed ID
28768171
PubMed Central ID
PMC5560103
Links
Grant list
R01 AI047389 / AI / NIAID NIH HHS / United States
R01 CA103866 / CA / NCI NIH HHS / United States
F30 CA189333 / CA / NCI NIH HHS / United States
T32 GM007753 / GM / NIGMS NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States