Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation.
The blood-brain barrier (BBB) and the glia limitans serve to prevent the migration of cells and other large molecules from the blood into the CNS. Neuroinflammatory diseases are characterized by disruption of the BBB and increased leukocyte infiltration into the CNS. In this issue of the JCI, Horng and colleagues demonstrate that astrocytes of the glia limitans induce tight junction formation in response to inflammatory cues, thereby tightening the border to limit the number of activated T cells infiltrating the CNS. Moreover, preventing the formation of this inducible barrier in mice increased disease severity in models of neuroinflammation. Together, the results of this study indicate that the inducible barrier of the glia limitans should be further explored as a therapeutic target.
|Year of Publication
J Clin Invest
2017 Aug 01
|PubMed Central ID
R01 ES025530 / ES / NIEHS NIH HHS / United States
R01 AI126880 / AI / NIAID NIH HHS / United States
R56 AI093903 / AI / NIAID NIH HHS / United States
R21 NS087867 / NS / NINDS NIH HHS / United States
R01 AI093903 / AI / NIAID NIH HHS / United States