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Cancer Cell DOI:10.1016/j.ccell.2018.03.007

Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Publication TypeJournal Article
Year of Publication2018
AuthorsTaylor, AM, Shih, J, Ha, G, Gao, GF, Zhang, X, Berger, AC, Schumacher, SE, Wang, C, Hu, H, Liu, J, Lazar, AJ, Cherniack, AD, Beroukhim, R, Meyerson, M
Corporate AuthorsCancer Genome Atlas Research Network
JournalCancer Cell
Volume33
Issue4
Pages676-689.e3
Date Published2018 Apr 09
ISSN1878-3686
Abstract

Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Aneuploidy was anti-correlated with expression of immune signaling genes, due to decreased leukocyte infiltrates in high-aneuploidy samples. Chromosome arm-level alterations show cancer-specific patterns, including loss of chromosome arm 3p in squamous cancers. We applied genome engineering to delete 3p in lung cells, causing decreased proliferation rescued in part by chromosome 3 duplication. This study defines genomic and phenotypic correlates of cancer aneuploidy and provides an experimental approach to study chromosome arm aneuploidy.

DOI10.1016/j.ccell.2018.03.007
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29622463?dopt=Abstract

Alternate JournalCancer Cell
PubMed ID29622463