Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.

Nat Methods
Authors
Keywords
Abstract

Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts.

Year of Publication
2018
Journal
Nat Methods
Volume
15
Issue
6
Pages
437-439
Date Published
2018 06
ISSN
1548-7105
DOI
10.1038/s41592-018-0007-1
PubMed ID
29735997
PubMed Central ID
PMC6202184
Links
Grant list
U24 CA160034 / CA / NCI NIH HHS / United States
R01 MH110049 / MH / NIMH NIH HHS / United States
U24 CA210986 / CA / NCI NIH HHS / United States
R01 HG009761 / HG / NHGRI NIH HHS / United States
U24 CA126476 / CA / NCI NIH HHS / United States
RM1 HG006193 / HG / NHGRI NIH HHS / United States