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Nat Methods DOI:10.1038/s41592-018-0007-1

Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.

Publication TypeJournal Article
Year of Publication2018
AuthorsMyers, SA, Wright, J, Peckner, R, Kalish, BT, Zhang, F, Carr, SA
JournalNat Methods
Date Published2018 May 07

Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts.


Alternate JournalNat. Methods
PubMed ID29735997