Nat Methods DOI:10.1038/s41592-018-0007-1

Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.

Publication Type	Journal Article
Year of Publication	2018
Authors	Myers, SA, Wright, J, Peckner, R, Kalish, BT, Zhang, F, Carr, SA
Journal	Nat Methods
Date Published	2018 May 07
ISSN	1548-7105
Abstract	Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts.
DOI	10.1038/s41592-018-0007-1
Pubmed	http://www.ncbi.nlm.nih.gov/pubmed/29735997?dopt=Abstract
Alternate Journal	Nat. Methods
PubMed ID	29735997

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