Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Nat Commun
Authors
Keywords
Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p 

Year of Publication
2017
Journal
Nat Commun
Volume
8
Issue
1
Pages
80
Date Published
2017 07 19
ISSN
2041-1723
DOI
10.1038/s41467-017-00031-7
PubMed ID
28724990
PubMed Central ID
PMC5517526
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UL1 RR033176 / RR / NCRR NIH HHS / United States
F31 AA025278 / AA / NIAAA NIH HHS / United States
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P60 AR049465 / AR / NIAMS NIH HHS / United States
R01 AR046838 / AR / NIAMS NIH HHS / United States
N01AG12100 / AG / NIA NIH HHS / United States
R01 AG024480 / AG / NIA NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
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RC2 AR058973 / AR / NIAMS NIH HHS / United States
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Wellcome Trust / United Kingdom
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F32 AR059469 / AR / NIAMS NIH HHS / United States
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WT098051 / Wellcome Trust / United Kingdom
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SP/04/002 / British Heart Foundation / United Kingdom
CZB/4/276 / Chief Scientist Office / United Kingdom
CZB/4/710 / Chief Scientist Office / United Kingdom
WT098017 / Wellcome Trust / United Kingdom