Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study.
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Abstract | Genetic factors contribute to the risk of bone fractures, partly because of effects on bone strength. High-resolution peripheral quantitative computed tomography (HR-pQCT) estimates bone strength using micro-finite element analysis (µFEA). The goal of this study was to investigate if the bone failure load estimated by HR-pQCT-based µFEA is heritable and to what extent it shares genetic regulation with areal bone mineral density (aBMD). Bone microarchitecture was measured by HR-pQCT at the ultradistal tibia and ultradistal radius in adults from the Framingham Heart Study (n = 1087, mean age 72 years; 57% women). Radial and tibial failure load in compression were estimated by µFEA. Femoral neck (FN) and ultradistal forearm (UD) aBMD were measured by dual-energy X-ray absorptiometry (DXA). Heritability (h ) of failure load and aBMD and genetic correlations between them was estimated adjusting for covariates (age and sex). Failure load values at the non-weight-bearing ultradistal radius and at the weight-bearing ultradistal tibia were highly correlated (r = 0.906; p |
Year of Publication | 2017
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Journal | J Bone Miner Res
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Volume | 32
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Issue | 11
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Pages | 2151-2156
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Date Published | 2017 Nov
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ISSN | 1523-4681
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DOI | 10.1002/jbmr.3200
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PubMed ID | 28722129
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PubMed Central ID | PMC5685872
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Grant list | R01 AR041398 / AR / NIAMS NIH HHS / United States
R01 AR061445 / AR / NIAMS NIH HHS / United States
R01 AR072199 / AR / NIAMS NIH HHS / United States
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