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Neuron DOI:10.1016/j.neuron.2017.03.017

Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia.

Publication TypeJournal Article
Year of Publication2017
AuthorsWallace, ML, Saunders, A, Huang, KWui, Philson, AC, Goldman, M, Macosko, EZ, McCarroll, SA, Sabatini, BL
Date Published2017 Apr 05
KeywordsAnimals, Basal Ganglia, Entopeduncular Nucleus, GABAergic Neurons, Gene Expression Profiling, Globus Pallidus, Glutamic Acid, Habenula, Humans, In Situ Hybridization, Fluorescence, Limbic System, Mice, Neostriatum, Neurons, Parvalbumins, Sensorimotor Cortex, Single-Cell Analysis, Somatostatin, Thalamus

The basal ganglia (BG) integrate inputs from diverse sensorimotor, limbic, and associative regions to guide action-selection and goal-directed behaviors. The entopeduncular nucleus (EP) is a major BG output nucleus and has been suggested to channel signals from distinct BG nuclei to target regions involved in diverse functions. Here we use single-cell transcriptional and molecular analyses to demonstrate that the EP contains at least three classes of projection neurons-glutamate/GABA co-releasing somatostatin neurons, glutamatergic parvalbumin neurons, and GABAergic parvalbumin neurons. These classes comprise functionally and anatomically distinct output pathways that differentially affect EP target regions, such as the lateral habenula (LHb) and thalamus. Furthermore, LHb- and thalamic-projecting EP neurons are differentially innervated by subclasses of striatal and pallidal neurons. Therefore, we identify previously unknown subdivisions within the EP and reveal the existence of cascading, molecularly distinct projections through striatum and globus pallidus to EP targets within epithalamus and thalamus.


Alternate JournalNeuron
PubMed ID28384468
PubMed Central IDPMC5439268
Grant List / / Howard Hughes Medical Institute / United States
R01 NS046579 / NS / NINDS NIH HHS / United States
R37 NS046579 / NS / NINDS NIH HHS / United States
T32 NS007484 / NS / NINDS NIH HHS / United States