Continuous immunotypes describe human immune variation and predict diverse responses.
The immune system consists of many specialized cell populations that communicate with each other to achieve systemic immune responses. Our analyses of various measured immune cell population frequencies in healthy humans and their responses to diverse stimuli show that human immune variation is continuous in nature, rather than characterized by discrete groups of similar individuals. We show that the same three key combinations of immune cell population frequencies can define an individual's immunotype and predict a diverse set of functional responses to cytokine stimulation. We find that, even though interindividual variations in specific cell population frequencies can be large, unrelated individuals of younger age have more homogeneous immunotypes than older individuals. Across age groups, cytomegalovirus seropositive individuals displayed immunotypes characteristic of older individuals. The conceptual framework for defining immunotypes suggested by our results could guide the development of better therapies that appropriately modulate collective immunotypes, rather than individual immune components.
|Year of Publication||
Proc Natl Acad Sci U S A
2017 07 25
|PubMed Central ID||
R01 HL120724 / HL / NHLBI NIH HHS / United States
U19 AI057229 / AI / NIAID NIH HHS / United States
HHMI / Howard Hughes Medical Institute / United States