Genetic control of autophagy underlies pathogenesis of inflammatory bowel disease.
Mucosal Immunol
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Abstract | Autophagy contributes to cellular homeostasis in the face of nutrient deprivation and other cellular stresses. Cell type-specific functions for autophagy are critical in maintaining homeostasis at both the tissue level and at the whole-organism level. Recent work has highlighted the ways in which human genetic variants modulate autophagy to alter epithelial and immune responses in inflammatory bowel disease. |
Year of Publication | 2017
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Journal | Mucosal Immunol
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Volume | 10
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Issue | 3
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Pages | 589-597
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Date Published | 2017 May
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ISSN | 1935-3456
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DOI | 10.1038/mi.2017.18
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PubMed ID | 28327616
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