Genetic control of autophagy underlies pathogenesis of inflammatory bowel disease.

Mucosal Immunol
Authors
Abstract

Autophagy contributes to cellular homeostasis in the face of nutrient deprivation and other cellular stresses. Cell type-specific functions for autophagy are critical in maintaining homeostasis at both the tissue level and at the whole-organism level. Recent work has highlighted the ways in which human genetic variants modulate autophagy to alter epithelial and immune responses in inflammatory bowel disease.

Year of Publication
2017
Journal
Mucosal Immunol
Volume
10
Issue
3
Pages
589-597
Date Published
2017 May
ISSN
1935-3456
DOI
10.1038/mi.2017.18
PubMed ID
28327616
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