Role of AHR and HIF-1α in Glioblastoma Metabolism.
Authors | |
Abstract | Glioblastoma (GBM) progression is associated with metabolic remodeling in both glioma and immune cells, resulting in the use of aerobic glycolysis as the main source of energy and biosynthetic molecules. The transcription factor hypoxia-inducible factor (HIF)-1α drives this metabolic reorganization. Oxygen levels, as well as other factors, control the activity of HIF-1α. In addition, the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) modulates tumor-specific immunity and can also participate in metabolic remodeling. AHR activity is regulated by tryptophan derivatives present in the tumor microenvironment. Thus, the tumor microenvironment and signaling via HIF-1α and AHR regulate the metabolism of gliomas and immune cells, modulating tumor-specific immunity and, consequently, tumor growth. Here, we review the roles of HIF-1α and AHR in cancer and immune cell metabolism in GBM. |
Year of Publication | 2017
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Journal | Trends Endocrinol Metab
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Volume | 28
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Issue | 6
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Pages | 428-436
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Date Published | 2017 Jun
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ISSN | 1879-3061
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DOI | 10.1016/j.tem.2017.02.009
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PubMed ID | 28318896
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PubMed Central ID | PMC5438779
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Links | |
Grant list | R01 AI093903 / AI / NIAID NIH HHS / United States
R01 AI126880 / AI / NIAID NIH HHS / United States
R01 ES025530 / ES / NIEHS NIH HHS / United States
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