Role of AHR and HIF-1α in Glioblastoma Metabolism.

Trends Endocrinol Metab
Authors
Abstract

Glioblastoma (GBM) progression is associated with metabolic remodeling in both glioma and immune cells, resulting in the use of aerobic glycolysis as the main source of energy and biosynthetic molecules. The transcription factor hypoxia-inducible factor (HIF)-1α drives this metabolic reorganization. Oxygen levels, as well as other factors, control the activity of HIF-1α. In addition, the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) modulates tumor-specific immunity and can also participate in metabolic remodeling. AHR activity is regulated by tryptophan derivatives present in the tumor microenvironment. Thus, the tumor microenvironment and signaling via HIF-1α and AHR regulate the metabolism of gliomas and immune cells, modulating tumor-specific immunity and, consequently, tumor growth. Here, we review the roles of HIF-1α and AHR in cancer and immune cell metabolism in GBM.

Year of Publication
2017
Journal
Trends Endocrinol Metab
Volume
28
Issue
6
Pages
428-436
Date Published
2017 Jun
ISSN
1879-3061
DOI
10.1016/j.tem.2017.02.009
PubMed ID
28318896
PubMed Central ID
PMC5438779
Links
Grant list
R01 AI093903 / AI / NIAID NIH HHS / United States
R01 AI126880 / AI / NIAID NIH HHS / United States
R01 ES025530 / ES / NIEHS NIH HHS / United States