Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.

Nat Immunol
Authors
Abstract

Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation.

Year of Publication
2017
Journal
Nat Immunol
Volume
18
Issue
4
Pages
412-421
Date Published
2017 Apr
ISSN
1529-2916
DOI
10.1038/ni.3683
PubMed ID
28166218
Links
Grant list
P30 CA093373 / CA / NCI NIH HHS / United States